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Interactions between the discoidin domain receptor 1 and  1 integrin regulate attachment to collagen

Overview of attention for article published in Biology Open, September 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
43 Mendeley
citeulike
1 CiteULike
Title
Interactions between the discoidin domain receptor 1 and  1 integrin regulate attachment to collagen
Published in
Biology Open, September 2013
DOI 10.1242/bio.20135090
Pubmed ID
Authors

L. A. Staudinger, S. J. Spano, W. Lee, N. Coelho, D. Rajshankar, M. P. Bendeck, T. Moriarty, C. A. McCulloch

Abstract

Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and discoidin domain receptors (DDR), to fibrillar collagen. While previous data suggest that these two receptors interact, the functional nature of these interactions is not defined. In mouse and human fibroblasts we examined the effects of DDR1 knockdown and over-expression on β1 integrin subunit function. DDR1 expression levels were positively associated with enhanced contraction of floating and attached collagen gels, increased collagen binding and increased collagen remodeling. In DDR1 over-expressing cells compared with control cells, there were increased numbers, area and length of focal adhesions immunostained for talin, paxillin, vinculin and activated β1 integrin. After treatment with the integrin-cleaving protease jararhagin, in comparison to controls, DDR1 over-expressing cells exhibited increased β1 integrin cleavage at the cell membrane, indicating that DDR1 over-expression affected the access and susceptibility of cell-surface β1 integrin to the protease. DDR1 over-expression was associated with increased glycosylation of the β1 integrin subunit, which when blocked by deoxymannojirimycin, reduced collagen binding. Collectively these data indicate that DDR1 regulates β1 integrin interactions with fibrillar collagen, which positively impacts the binding step of collagen phagocytosis and collagen remodeling.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Denmark 1 2%
Canada 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 37%
Researcher 7 16%
Student > Doctoral Student 5 12%
Student > Master 4 9%
Student > Bachelor 3 7%
Other 6 14%
Unknown 2 5%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 33%
Agricultural and Biological Sciences 11 26%
Medicine and Dentistry 5 12%
Engineering 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 9%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2018.
All research outputs
#7,829,078
of 13,927,501 outputs
Outputs from Biology Open
#431
of 1,088 outputs
Outputs of similar age
#110,205
of 252,336 outputs
Outputs of similar age from Biology Open
#10
of 29 outputs
Altmetric has tracked 13,927,501 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,088 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.