↓ Skip to main content

The Company of Biologists

Article Metrics

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

Overview of attention for article published in Development (09501991), February 2013
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
4 tweeters
video
1 video uploader

Citations

dimensions_citation
45 Dimensions

Readers on

mendeley
55 Mendeley
Title
Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells
Published in
Development (09501991), February 2013
DOI 10.1242/dev.087528
Pubmed ID
Authors

Taha Adnan Jan, Renjie Chai, Zahra Nabi Sayyid, Renée van Amerongen, Anping Xia, Tian Wang, Saku Tapani Sinkkonen, Yi Arial Zeng, Jared Ruben Levin, Stefan Heller, Roel Nusse, Alan Gi-Lun Cheng

Abstract

Permanent hearing loss is caused by the irreversible damage of cochlear sensory hair cells and nonsensory supporting cells. In the postnatal cochlea, the sensory epithelium is terminally differentiated, whereas tympanic border cells (TBCs) beneath the sensory epithelium are proliferative. The functions of TBCs are poorly characterized. Using an Axin2(lacZ) Wnt reporter mouse, we found transient but robust Wnt signaling and proliferation in TBCs during the first 3 postnatal weeks, when the number of TBCs decreases. In vivo lineage tracing shows that a subset of hair cells and supporting cells is derived postnatally from Axin2-expressing TBCs. In cochlear explants, Wnt agonists stimulated the proliferation of TBCs, whereas Wnt inhibitors suppressed it. In addition, purified Axin2(lacZ) cells were clonogenic and self-renewing in culture in a Wnt-dependent manner, and were able to differentiate into hair cell-like and supporting cell-like cells. Taken together, our data indicate that Axin2-positive TBCs are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 7%
Portugal 1 2%
United Kingdom 1 2%
Hungary 1 2%
Netherlands 1 2%
Unknown 47 85%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 24%
Student > Ph. D. Student 11 20%
Professor > Associate Professor 5 9%
Other 5 9%
Student > Doctoral Student 4 7%
Other 17 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 36%
Biochemistry, Genetics and Molecular Biology 16 29%
Unspecified 6 11%
Medicine and Dentistry 5 9%
Neuroscience 5 9%
Other 3 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2018.
All research outputs
#493,763
of 11,946,339 outputs
Outputs from Development (09501991)
#204
of 5,353 outputs
Outputs of similar age
#5,816
of 132,020 outputs
Outputs of similar age from Development (09501991)
#1
of 32 outputs
Altmetric has tracked 11,946,339 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,353 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.